Debridement focusing on removal of pulp remnants, as well as microorganisms and microbial toxins from the root canal system, is considered essential for endodontic success. However, current endodontic techniques fall short of the goal to remove all infective microorganisms and debris consistently. This is mainly due to the complex anatomy of the root canal system, the type of bacteria and resistance of bacterial colonization, the limitation of rotary instrumentation to remove all tissue from the surfaces after completion of the preparation and the limited potential for commonly used irrigants to penetrate the dentin walls. This presentation will explore the ability of laser photonic radiation to enhance the efficacy of irrigants to improve the decontamination of the three dimensional root canal system.